We’ve all read about the guy who else bet on the underdog team throughout the Superbowl plus walked away along with thousands of bucks, and also the friend regarding a friend who else knows a person that may hook you up with a Philippine cock fight next weekend.
If if you’re a fan of sports, it’s a pretty safe predictions to say you know that betting, both lawful and illegal, takes place on practically every professional game and several college games.
Basically placing a wager could be a confusing affair — sports publications have their own vocabulary, as well as the systems fluctuate. Understanding how in order to bet well enough to be able to make some cash is yet another matter completely. How are the odds determined? Who units the line? Just what percentage of typically the time do you need to win to break even?
In this article I’ll allow you to acquainted with the terminology in the planet of betting and even odds making and possess you how one of the tour’s favorite pastimes can earn you a new lot of funds whenever you know exactly what you are doing.
Sports Betting Basics
Different sports have various systems for oddsmaking and betting. Right now there are even diverse systems for the particular same sport, based on what kind of game the bettor wants to enjoy. But to recognize these systems, an individual first need to recognize the jargon.
Motion – Action is actually betting activity. Terms such as “I want in on the action” or perhaps “Show me where the action is” come from this kind of term. Since betting on sports will be illegal in a lot of places, weight loss constantly look up the local bookie in typically the phone book.
Inconveniente – In athletics betting, “to handicap” is to give one team a details advantage in purchase to level the betting field.
Sportsbook – An institution that takes gamble, also known because an e book. An individual who takes wagers is a bookie.
Juice – This is the percentage of all wagers used by the bookie as profit. The particular juice is also known as the particular vig, short regarding vigorish. Sometimes betting shops have a straight proportion in the handle, although more often the vig is figured directly into the odds
Handle – The deal with is the total amount of cash wagered on the subject of bets. Super Dish betting generates the particular biggest handle involving the year for some bookies.
The pass on – The level spread is utilized in high-scoring athletics like football and basketball. It is basically a handicap used to make most games competitive within the eyes of gamblers. The spread presents one team an edge of a few points. คาสิโนถอนไว for the level spread shows typically the favored team initial, followed by some sort of negative number (the actual spread). The home team is definitely shown in capital letters.
You can easily make sports gamble on football, sports, baseball, basketball… okay pretty much any kind of sporting event on earth and you can easily make a fortune coming from it, if an individual do it the right way. In case you’ve ever wished to place a bet yourself, yet weren’t really positive on if that was worth the particular risk, you include come to the correct place. Gambling inside its very certainly means someone needs to win and a person has to lose. What if you can find a method to tip the particular balance and always be within the winning side with nearly every sole bet you make.
Sporting activities betting systems are usually proven ways to be able to aid in increasing the possibilities of winning any time betting in athletics. Professional bettors and even handicappers have developed these systems to be able to allow us novice bettors to understand the interior tricks and trades that they use to be so successful inside sports betting.
Sports activities betting systems pertains to an established of events of which when combined for a game for the particular sport symbolizes a profitable bets scenario. Since sporting activities betting involves humans, there is no more deterministic edge in order to the house and also the gambler. The techniques allow the a person the gambler to be able to have an border.
To be able to reach to the highest possible number of viewers and to make them better acquainted with the opportunities and propositions of the online casino, is a personal goal of almost all the proprietors of online casino houses. The goal is a rejoinder of the significance of valuable marketing and propagandizing schemes. The crucial role they have in the popularization of an online casino cannot be refuted situs bola sbobet 88 .
Casino Link building is a means to create a network of promotional contents and links in the internet that will direct people to the intentioned website. It is done through various methods such as purchase of links on other websites, promotion through articles and net contents, blogging, posting and commenting about the website, so on and so forth. Obtaining casino links on payment perhaps will be the first to grab your attention among the many.
The format of the scheme is such that it allows you to reserve links for your own online casino, in other websites. One has to follow a small set of steps in order to purchase the link on the particular website, which will be displaying the casino link. The websites chosen for the purpose are quintessentially those, which are associated with online gaming, gambling, online casinos, and virtual games.
This promises a good audience from people who are more likely to be interested in your website attending to the wishes of online gambling and casinos. It is an inclusive strategy that clearly concerns with those who crave for virtual gambling, thus, highly profitable in the long run for your online business.
Publishing of website related content on other popular gambling and gaming destinations in the internet also vouchsafe good response, however, they might be difficult to cope up with. The articles written for the promotion of the online casino, and the posting, blogging and commenting should not only be adept in arousing interest among the viewer, but at the same time should be brief, steady, and relevant for the purpose.
Apart from this, the general qualifications such as sound language and clear sense also matter. Besides, the search engines should be able to direct to the content matter easily when someone applies for it. All proficient casino SEO service providers will be ready to render their facilities in this matter, however,at a certain charge for the content materials. These are nonetheless, relatively small investments when compared to the necessary boost with which it will supplicate an advantageous position to your business.
Their training qualifies them to provide personalized holistic recommendations to clients at all ages and stages of their life and health. You assume all responsibility for notifying us of changes in credit card numbers and/or expiration dates or in any change in status of the applicable bank account, as the case may be. If your credit card is denied when charged or if an ACH or other debit to the depositary account is rejected, we may charge and collect from you a “bad account” fee of twenty five ($25.00) dollars for any declined or rejected transaction. You shall additionally be responsible for and shall immediately pay us, on demand, any payments that are made to us that are subject to a subsequent reversal. Questions regarding charges must be brought to the attention of Company’s billing department within 90 days after the end of the questioned billing period.
The guide takes all guesswork out of the kitchen, helping you melt fat, recharge energy levels, and skyrocket testosterone, among other benefits. One of the safest and most effective naturally derived “herbal antipsychotics” is CBD, or Cannabidiol. It’s an herbal cannabinoid that has promising results with various issues. Musical therapy is a sub-type of psychotherapy that involves an individual listening to music as a means of improving both communication and interpersonal skills. Most types of music therapy are based loosely around traditional cognitive-behavioral therapy.
Look for L-cysteine supplements based on plant sources and suitable for vegans and vegetarians. L-cysteine is also commonly used in the paracetamol overdose treatment. Medical research has shown that L-cysteine supplementation combined with mesalamine can help reduce the symptoms of inflammatory bowel diseases (ulcerative colitis and Crohn’s disease). This nutrition plan teaches you what to eat over a 12-week period to achieve a body you never thought was possible at your age.
Doctors said to have 2nd stem cell transplant but dad do not want that again because he is very weak to withstand transplant. We are desperately looking for the cure as dad is very ill. I have been taking the apricot kernels for fifteen months now after surgery for breast cancer. I did not do radiation, chemo or take any meds.
225I want the Police where I live to protect me from the Jungle. If they think every single action they take will land them in jail, the will not do that. Then we will have to protect ourselves and all hell will break out. If you’re going to kill somebody who’s attacking you today, that person better also be white. 220Yea, and all this could be avoided if the taser had the “trigger” on the back to be pushed by the thumb .
CBD, by activating the cannabinoid receptor, CB2, has been shown to induce vasodilatation in type 2 diabetic rats , and by activating 5-HT1A receptors, CBD showed a therapeutic effect in diabetic neuropathy . Moreover, this phytocannabinoid accelerated wound healing in a diabetic rat model by protecting the endothelial growth factor . In addition, by preventing the formation of oxidative stress in the retina neurons of diabetic animals, CBD counteracted tyrosine nitration, which can lead to glutamate accumulation and neuronal cell death .
Scuderi C., Steardo L., Esposito G. Cannabidiol promotes amyloid precursor protein ubiquitination and reduction of beta amyloid expression in SHSY5YAPP+ cells through PPARγ involvement. Wu H.Y., Han T.R. Cannabidiol hydroxyquinone-induced apoptosis of splenocytes is mediated predominantly by thiol depletion. Wheal A.J., Cipriano M., Fowler C.J., Randall M.D., O’Sullivan S.E. Cannabidiol improves vasorelaxation in Zucker diabetic fatty rats through cyclooxygenase activation.
Yang K.H., Galadari S., Isaev D., Petroianu G., Shippenberg T.S., Oz M. The nonpsychoactive cannabinoid cannabidiol inhibits 5- hydroxytryptamine3A receptor-mediated currents in xenopus laevis oocytes. Kozela E., Lev N., Kaushansky N., Eilam R., Rimmerman N., Levy R., Ben-Nun A., Juknat A., Vogel Z. Cannabidiol inhibits pathogenic T cells, decreases spinal microglial activation and ameliorates multiple sclerosis-like disease in C57BL/6 mice. It’s similar to an engine running without gas and oil. The engine may still run without enough oil, but it’s sustaining damage that will eventually kill it. The same might be true if you watered down the gas to make it last longer.
By lowering ROS levels, CBD also protects non-enzymatic antioxidants, preventing their oxidation, as in the case of GSH in the myocardial tissue of C57BL/6J mice with diabetic cardiomyopathy and doxorubicin-treated rats . An increase in GSH levels after CBD treatment was also observed in mouse microglia cells and in the liver of cadmium poisoned mice . This is of great practical importance because GSH cooperates with other low molecular weight compounds in antioxidant action, mainly with vitamins such as A, E, and C . CBD exhibits much more antioxidant activity (30–50%) than α-tocopherol or vitamin C . I have a rare form of sarcoma cancer and four months ago was given 12 months to live.
Whats Your Primary Health Focus?
272 If nothing else, taser should, by law, be painted bright yellow, and all law enforcement pistols should be black, or traditional blued steel. 267After the Chauvin case, there’s really no limit. Common sense and a medical examiner’s report no longer count for anything. “Race” had absolutely nothing to do with the case – the lynch mob/”state” didn’t even claim it did – but the country is degraded and pathetic enough to kill dozens and ruin thousands of lives and cause billions in damage because of a non-case.
Smeriglio A., Giofrè S., Galati E.M., Monforte M.T., Cicero N., D’Angelo V., Grassi G., Circosta C. Inhibition of aldose reductase activity by Cannabis sativa chemotypes extracts with high content of cannabidiol or cannabigerol. CBD also reduces reactive oxygen species production by chelating transition metal ions involved in the Fenton reaction to form extremely reactive hydroxyl radicals . It was shown that CBD, acting similarly to the classic antioxidant butylated hydroxytoluene , prevents dihydrorodamine oxidation in the Fenton reaction . In addition, CBD has been found to decrease β-amyloid formation in neurons by reducing the concentration of transition metal ions .
Table presenting the number of identified CBD targets and percentage of specific Gα proteins coupled to GPCR receptors and ion permeability of both ion channels and ionotropic receptors. The total number of final effects on cell membrane potential was calculated based on the type of Gα proteins coupled to GPCR receptors targeted by CBD and ion permeability of those targets together with pharmacological action of CBD . These changes help increase the tolerance for the drugs that compels the user to increase size and frequency of doses.
On the other hand, GSK-3β is decreased by PPARγ stimulation . CBD has been shown to affect redox balance by modifying the level and activity of both oxidants and antioxidants . CBD, like other antioxidants, interrupts free radical chain reactions, capturing free radicals or transforming them into less active forms. 440″392 Jacob Blake had a restraining order against him. He resisted arrest, fought the cops and then just reached for a knife and he was shot multiple times and left paralyzed. The officer who shot him is now back on the job. 419I do have a problem with cops screaming at you and if you don’t – because you’re confused, don’t understand, whatever reason – they can deal out instant death.
This is a natural substance used by the brain to basically improve communication between neurons. It has been used effectively for any type of age related mental functioning decline as well as for Alzheimer’s, ADHD, depression and for the improvement CBD Drink Mixes of athletic performance. Phosphatidyl choline is a similar but weaker version of PS, and one needs at least 24 grams of the stuff daily to accomplish the same benefits. 5) Vitamin B12– 5000 mcg methylcobalamin daily dissolved under the tongue.
When the drugs wear off, the emotional pain can be too much to process all at once. An addict will often act out those emotions until he can calm them with more drugs. While your brain is handling pain responses, it’s also keeping your heart beating, regulating your body temperature and managing respiration. CBD-Öl-Tinktur FAQs Your brain is the ultimate multitasker with some very important responsibilities, and it manages all of this with a chemical messaging system. Del Río C., Navarrete C., Collado J.A., Bellido M.L., Gómez-Cañas M., Pazos M.R., Fernández-Ruiz J., Pollastro F., Appendino G., Calzado M.A., et al.
Apricot Kernels For Cancer: The Real Story Of Laetrile
I have friends who used the seeds who had only weeks to live and they all are well now. My friend who got me on to these pills tells me I should take way more than 4/day, but as I read other information on these seeds, I’m not sure it’s okay to increase the amount. I would really appreciate if you could help me.
2 The Consequences Of Direct Antioxidant Action Of Cbd
If you keep in mind that one seed is +/- 20 mg the last woul mean that you take 1000 seeds per day. I’ve been eating between 15 and 20 of them a day for years now. At the beginning, eating them made me sneeze , but now it doesn’t any more and I find them delicious.
How Different Drugs Work On Your Brain
….& chemo isn’t toxic poison …..I would much rather try apricot kernels any day & they explain it well……other foods also have natural cyanide in them……. Hi Dana, It is recommended that you gradually introduce these potent seeds to your diet. A good rule of thumb is about 1 apricot kernel for every 10 pounds of body weight. Evelyn So if you weigh 150 pounds, then you would consume 15 per day, spread out throughout the day. For serious health issues, some have taken 25 – 40 per day. V” is a natural health pioneer with over 30 years active practice in Bio-Energetics, Digital Thermography, Meridian Stress Analysis, Homeopathy, and Chiropractic.
It has been suggested that its action may be due to a weak affinity for CB1 and CB2 receptors . There is no published data examining their impact on the redox balance. The result of an imbalance between oxidants and antioxidants is oxidative stress, the consequences of which are oxidative modifications of lipids, nucleic acids, and proteins. This results in changes in the structure of the above molecules and, as a result, disrupts their molecular interactions and signal transduction pathways . Oxidative modifications play an important role in the functioning of redox-sensitive transcription factors (including Nrf2 and the nuclear factor kappa B (NFκB). As a consequence, oxidative modifications play a role in the regulation of pathological conditions characterized by redox imbalances and inflammation, such as cancer, inflammatory diseases, and neurodegenerative diseases .
RxISK.org adds 320,172 Health Canada reports of adverse events to its drug safety database RxISK.org, the first free, independent website… Established in 1989, Vitality magazine is one of Canada’s largest publications on natural health, alternative medicine, and green living. At vitalitymagazine.com we bring you highlights of our current issue plus exclusive CBD Gummies With THC web material, and archives of selected content from past issues. JanYou mention ‘anti vaxers’ causing great harm to society’, and then that you are sceptical about aluminum being safe. Are you aware that most vaccines contain aluminum? In my opinion anti vaxers are not the scum of the earth as you are portraying them, this is propaganda to enable an agenda.
The cannabinoid quinol VCE-004.8 alleviates bleomycin-induced scleroderma and exerts potent antifibrotic effects through peroxisome proliferator-activated receptor-γ and CB2 pathways. Sultan A.S., Marie M.A., Sheweita S.A. Novel mechanism of cannabidiol-induced apoptosis in breast cancer cell lines. Jean-Gilles L., Braitch M., Latif M.L., Aram J., Fahey A.J., Edwards L.J., Robins R.A., Tanasescu R., Tighe P.J., Gran B., et al. Effects of pro-inflammatory cytokines on cannabinoid CB1 and CB2 receptors in immune cells. Da Silva V.K., De Freitas B.S., Garcia R.C.L., Monteiro R.T., Hallak J.E., Zuardi A.W., Crippa J.A.S., Schröder N. Antiapoptotic effects of cannabidiol in an experimental model of cognitive decline induced by brain iron overload. Indirect antioxidant and anti-inflammatory effects of CBD (closed arrows indicate inhibition; opened arrows indicate activation.
Your complex brain is extremely precious to life as we know it, and warrants protecting. O’Sullivan S.E. An update on PPAR activation by cannabinoids. Hoeflich K.P., Luo J., Rubie E.A., Tsao M.S., Jin O., Woodgett J.R. Requirement for glycogen synthase kinase-3beta in cell survival and NFkappaB activation. Lipina C., Hundal H.S. Modulation of cellular redox homeostasis by the endocannabinoid system. De Petrocellis L., Ligresti A., Moriello A.S., Allarà M., Bisogno T., Petrosino S., Stott C.G., Di Marzo V. Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes. Laprairie R.B., Bagher A.M., Kelly M.E., Denovan-Wright E.M. Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor.
Then, twenty years later, Dr. Ernest Krebs, a biochemist with a desire to understand what makes cancer cells work, discovered McCarrison’s writing about apricot kernels. Krebs also began studying the lifestyle habits of the Hunzas. I mentioned in my book on vitamin D that receptors do exist in the brain for this hormone-like vitamin. Vitamin D is anti-inflammatory, and the evidence is clear that vitamin D levels are tied intimately to optimal brain function.
I make my own ginger tea and drink that every day and eat a piece of the ginger when I make the tea. The sweet apricot kernels are about 6 times weaker than the bitter. Start with 3 sweet apricot kernels and then increase to taking 3 sweet apricot kernels 3-4 times per day with a couple hours apart. Apple seeds are about 3.5 times weaker than BITTER apricot kernels. Bitter ALMONDS are about 3.5 times STRONGER than bitter apricot kernels.
However, five of 16 patients reported a two-point or greater reduction in pain . Although there are many cannabinoids present in cannabis, Δ9tetrahydrocannabinol (Δ9-THC) and cannabidiol are the two components found in the highest concentrations. CBD itself does not produce typical behavioral cannabimimetic effects and was thought not to be responsible for psychotropic effects of cannabis. Numerous anecdotal findings testify to the therapeutic effects of CBD, which in some cases were further supported by research findings.
It has been discovered that by alleviating glutathione L-cysteine supplements may be effective in treating male infertility, if it is caused by oxidative stress which leads to DNA damage and poor semen quality. A 2016 study published in the International Journal of Fertility and Sterility found that the percentage of men able to induce pregnancy in the supplemented with L-cysteine group was over 30 percent higher. L-cysteine has been suggested as an antidote for the negative effects of excessive alcohol intake, such as liver damage or hangover.
Try not thinking in such a modern, first world state of mind. Not every people are fortunate enough to have access to the materials that exist in other areas of the world. Hi John, you can use the kernals in the plum seeds.
Healing the damage caused by long-term drug abuse is a two-step process. First, the changes in brain structures and chemistry that perpetuate the addiction need to be reversed. As long as the brain is working against recovery, we will be fighting a losing battle. The second step is to restore lost cognitive function. Most mental illnesses have to do with abnormal brain chemistry.
CB1 and CB2 are primary couple with the Gαi/o subunit, which inhibits adenylate cyclase activity and therefore lowers intracellular Ca2+ concentration. In addition to surgically induced neuropathy, chronic pain can be triggered by chemical substance administration. For example, chemotherapeutic paclitaxel might be responsible for peripheral neuropathy development in humans. In several studies of PAC-induced neuropathic pain, CBD exerted a positive effect against mechanical and thermal allodynia in mice and prevented mechanical sensitivity.
A high dosage of calcium ascorbate, say 30 mg or so every four hours is important. Ascorbate (Vit. C) does not last any longer than about four hours in the system. The liver can make any other vitamin we need if it has enough ascorbate; it uses what it needs and then excretes the rest. Here in Australia about 50 years ago Dr. Archie Kalakorinos and Dr. Glen Dettman were using massive doses of ascorbate with amazing results. His book “Every Second Child” tells his story. The substance Laetrile was created by Dr. Ernest Krebs as a concentrated form of amygdalin obtained by extracting it from apricot kernels.
McPartland J.M., Duncan M., Di Marzo V., Pertwee R.G. Are cannabidiol and Δ9-tetrahydrocannabivarin negative modulators of the endocannabinoid system? Cornicelli J.A., Gilman S.R., Krom B.A., Kottke B.A. Cannabinoids impair the formation of cholesteryl ester in cultured human cells. Fišar Z., Singh N., Hroudová J. Cannabinoid-induced changes in respiration of brain mitochondria. Ahrens J., Demir R., Leuwer M., De La Roche J., Krampfl K., Foadi N., Karst M., Haeseler G. The nonpsychotropic cannabinoid cannabidiol modulates and directly activates alpha-1 and alpha-1-beta glycine receptor function.
It gets used to the presence of this drug and takes it as the new normal. The new pathways begin to hardwire your brain for maintaining your heart rate within a normal range with this drug as part of the equation. Many drugs deliver too much of a good thing when it comes to their interaction with the reward system of the brain.
TRPV1 agonists, such as capsaicin and AEA, have been shown to inhibit 2-AG synthesis in striatal neurons of C57BL/6 mice by glutathione-dependent pathways, since DAGL is stimulated by GSH . In addition, the interaction between AEA and 2-AG has been shown to disappear How do Vegan CBD Gummies compare to standard gummies? after inactivation of TRPV1 channels. This suggests that the negative effect of AEA on 2-AG metabolism can be mimicked by stimulation of TRPV1 channels. Therefore, AEA and 2-AG interactions require redox balance, due to the participation of GSH in 2-AG synthesis.
One of the reasons neurotransmitters might not be received is that all the appropriate receptors are blocked. If a receptor is already engaged, it cannot take on a neurotransmitter. Receptor cells can only connect with their intended neurotransmitters, and only in a one-to-one relationship.
Drug Use And Mental Illness: Confusion In The Brain
Its my dad’s strong Will to fight that he survived. After transplant, we need to take good care of diet, make sure patient do not pick up any sort of infections like fever, cold, cough, diarrhoea etc…. Generally seasonal flu…during summers, my dad sufferred from diarrhoea coz in India its too hot and during wintes, dad catches cold and flu sometimes pneumonia. After transplant, once patient began to develop platelets, then is the time to relax for family but one should keep an eye on blood tests regularly.
Known as a potent anti-inflammatory for the whole body, curcumin boosts overall cognitive function and has recently been shown to be an effective antidepressant. Make sure the brand of curcumin you buy is the natural BCM95 type due to its very high absorption and bioavailability. Some other brands use synthetic curcumin derived from petrochemicals, which are poor copies of natural curcumin and do not have the same benefits.
This effect of L-cysteine is the result of its ability to counteract the poisonous effects of acetaldehyde, which is a dangerous neurotoxin and by-product of alcohol metabolism in our body. L-cysteine helps convert acetaldehyde to the relatively harmless acetic acid. In one study, rats that were exposed to a lethal dose of acetaldehyde had very high survival rates after receiving L-cysteine. Nutrition can play a huge role in improving mental health.
Every drug you take has more than one effect on you. The brain stem, the part of the brain that attaches to the spinal cord, manages basic life support functions. The heart rate, respiration, and blood pressure are all controlled by the brain stem. With such great responsibilities, your brain is an extremely complex network of cells and chemicals that we continue to fruitfully study. While a lot of brain science is understood, there are still several questions to be answered. Your brain uses neurotransmitters to send signals from cell to cell.
9 Adenosine A2a Receptors
When you start combining drugs, the complications multiply. These drugs interact with the reward system in the brain. They increase dopamine activity, which is how How to Dose Delta-10 Gummies they produce the euphoric feeling. Their actions in the reward system are similar to that of morphine or nicotine — two drugs known to be extremely addictive.
To incerase platelets in blood, doctors recommended to eat kiwi as kiwi has something natural in it that increases platelets. Gradually, hair appears on body, appetite build up, and back to normal. But keep in mind the WILL to fight and survive which bring my dad back in 2007. But in 2013, multiole myeloma started to showing up slight signs in dad’s blood….and since then its growing up…..
After all, even antipsychotic medications aren’t perfect because researchers still aren’t sure what causes schizophrenia in the first place. Even though natural remedies may not be as potent as an antipsychotic medication, it is important to highlight the fact that some people have successfully managed their symptoms with these remedies. Unlike CBD isolates, our full-spectrum hemp features not only CBD but also may contain cannabinol , cannabichromene , cannabigerol and terpenes. We believe in the benefits of full-spectrum CBD hemp, since the endocannabinoid system has receptors for all of these cannabinoids. Serpell M., Ratcliffe S., Hovorka J., Schofield M., Taylor L., Lauder H., Ehler E. A double-blind, randomized, placebo-controlled, parallel group study of THC/CBD spray in peripheral neuropathic pain treatment. Mijangos-Moreno S., Poot-Aké A., Arankowsky-Sandoval G., Murillo-Rodríguez E. Intrahypothalamic injection of cannabidiol increases the extracellular levels of adenosine in nucleus accumbens in rats.
The Hunzas seemed to enjoyed near-perfect health and had none of the conditions common in the modern world, such as diabetes, obesity, heart attack, and cancer. He encountered this hardy community while he was working with the Indian Medical Service. According McCarrison’s written observations, the Hunzas seemed to enjoyed near-perfect health. Some lived to be over 135 years old and no one in their clan had any of the conditions so common in the modern world, such as diabetes, obesity, heart attack, and cancer. L-cysteine supplementation can be even more effective when used with vitamin C, vitamin E, vitamin B6, folic acid, sublingual methylcobalamin and selenium.
Neuropathic pain arises from direct nerve damage or a disease and affects the somatosensory nervous system. Hyperalgesia, an excessive pain sensation, might be accompanied by allodynia, a painful sensation of neutral stimulus. Neuropathic pain is persistent and difficult to relieve; therefore, identification of novel, more effective therapeutic strategies is needed. Plasticity is like losing your right hand in an accident and learning to write with your left. Since many brain functions are spread out over different areas of the brain, it’s possible to build new language skills, for instance, when the original center of language has been destroyed.
I will skip what I think of the trial outcome, the jury did its work, everything else is now moot with respect to whether or not this was a just verdict. What is not moot is this is another incident that marks a nation that is quickly devolving into something resembling a lawless third country such as Somila or Venezuela. 462Cops should know by now that they shouldn’t respond to calls in black neighborhoods or try to arrest black people if they are white, Asian or Hispanic. That’s where we are at after Floyd and the propaganda.
Petrosino S., Verde R., Vaia M., Allaraà M., Iuvone T., Marzo V.D. Anti-inflammatory properties of cannabidiol, a non-psychotropic cannabinoid, in experimental allergic contact dermatitis. McPartland J.M., Duncan M., Di Marzo V., Pertwee R.G. Are cannabidiol and tetrahydrocannabivarin negative modulators of the endocannabinoid system? Cheng D., Low J.K., Logge W., Garner B., Karl T. Chronic cannabidiol treatment improves social and object recognition in double transgenic APPswe/PS1∆E9 mice. Rajesh M., Mukhopadhyay P., Bátkai S., Haskó G., Liaudet L., Drel V.R., Obrosova I.G., Pacher P. Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption. CBD has potential antioxidant properties because its free cationic radicals exhibit several resonance structures in which unpaired electrons are distributed mainly on ether and alkyl moieties, as well as on the benzene ring .
It would’ve been different had he’d committed the worst sin on the face of humanity. Did she draw the wrong weapon and then discharge it in a gigantic mistake? They can always feed her to the mob…which, if you belive the verdict was too harsh, they’ve already started to do.
Cannabinoids produce a euphoric feeling and enhance sensory perception while creating irregular heartbeat, lack of focus and memory loss. Long believed to be rather harmless, cannabinoids have recently been more thoroughly studied. In the brain, marijuana and any other drug containing this compound kills cells, shrinks neurons and causes DNA fragmentation. Xu J., Bian X., Liu Y., Hong L., Teng T., Sun Y., Xu Z. Adenosine A2 receptor activation ameliorates mitochondrial oxidative stress upon reperfusion through the posttranslational modification of NDUFV2 subunit of complex I in the heart. Vallée A., Lecarpentier Y., Guillevin R., Vallée J.N. Effects of cannabidiol interactions with Wnt/β-catenin pathway and PPARγ on oxidative stress and neuroinflammation in Alzheimer’s disease.
Biological Activity Of Cbd
283Personally, I’d just eliminate tasers from cop equipment. But that’s because I’m fine with shooting people who resist arrest. I understand that lots of people aren’t going to see it this way. But I don’t think policing is viable at all if arrestees have the option of turning any arrest Quel produit au CBD choisir ? into a WWE match and we then scrutinize the cops’ response for meticulous compliance with rules. 275The donks won’t be satisfied until a black can commit premeditated murder and get away with it and any interference in getting away with murder will be subject to the stiffest of penalties.
Yes, apple seeds are also beneficial – which is why I use the whole core in smoothies and juicing. I also take 500mg capsule per day as recommended on the bottle for preventative purposes. Of course, it would be more if you had cancer. And as young people here shell the peas and consume a lot more than they put in the pan, which is exactly what we did and we found the kernels to be absolutely sublime.
White guys don’t do that because their experience with cops doesn’t go that far usually or that often to where they experience struggling gets rewarded. Altho they are shot and killed by cops more than Blacks are. One of the greatest hitters of all time but what’s his expertise in this case. I live in a burg that has been flooded with blue city refugees. About to go through another round of lease renewals, 15% increase in rents across the board. The bennies and pension are too good to give up.
HealingStrong, a nonprofit organization, is supported 100% by volunteers, who are experienced in using natural strategies. The organization’s mission is to educate, encourage, equip, and empower those seeking comprehensive natural strategies to heal strong and stay strong. The best advice we can give you is to consult with one of the doctors we interviewed in the Global series. I have just Been diagnosed with Invasive breast carcinoma, they want me to start Chemotherapy As soon as possible. Do you think eating the Apricot kernes now will help. I read to keep it below 60 per day, but I think using the weight estimate is the best way to decide how many since it is based on your weight and not one-size-fits-all.
I have arranged apricot kernel seeds from the market in india. I read somewhere for these seeds to be affective they need to be combined with other herbs and vitamins, now I cant find where I read that. I have been juicing 5 lbs of carrots daily for 2 months now, hoping for good results, but recent ct scan has shown my tumor grew half inch in total circumference. Where do you get thes apricot kernels and how to use it. I would look into Cannabis oil, bloodroot and the seeds..
Direct antioxidant effects of CBD (closed arrows indicate reducing effects; opened arrows indicate inducing action). However, the open CBD ring in the C-4 position is inactive. Due to the hydroxyl groups (C-1′ and C-5′ in the B ring), CBD can also bind to amino acids such as threonine, tyrosine, glutamic acid, or glutamine by means of a hydrogen bond . I agree with the sentiment that if you’re a cop in Minnesota, you should transfer somewhere else. If you LIVE there, you have your life in your own hands and should seriously consider cutting bait….
Some food sources include free-range eggs and wild Pacific salmon. Omega-3 fats prevents brain cell damage and lowers the risk of Alzheimer’s primarily by controlling chronic inflammation. Rajesh M., Mukhopadhyay P., Btkai S., Patel V., Saito K., Matsumoto S., Kashiwaya Y., Horvth B., Mukhopadhyay B., Becker L., et al. Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy. There is evidence to suggest that, when the brain is flooded with dopamine from drug abuse, the dopamine receptors change in response.
Because anyone is going to make the choice to do what will not have their life ruined forever. Especially when their efforts to do their job are negated by the local DA and mayor refusing to keep criminals in jail. As in “roll down your windows to make it easier for thieves” San Francisco and Los Angeles. As in “board up your stores to prevent looting” New York City. 254The donks won’t be satisfied until a black can commit premeditated murder and get away with it and any interference in getting away with murder will be subject to the stiffest of penalties. We see countless people running from cops in cars.
It was such a common mistake that some departments changed the location on the belt or eliminated tasers altogether. 329There were two male cops wrestling with the perp, and losing, if I recall the video correctly. She shouted “taser taser taser” to get them out of the line of fire. How many “Oops, I thought my gun was a taser” incidents do we have on an annual basis. I’m guessing not enough to warrant the complete re-equipping of every police force in America.
I’ve only got the opportunity associated with betting with John Morrison’s Sports Bets Champ system since March 2009 in addition to I’ve made 19 bets to date.
My partner and i bought the method with a somewhat poor time because it was the really end of the particular NBA betting period, and before typically the MLB season started out, so I were required to wait for the long time for making any bets. I wish I would have got found this possibility sooner, because the NBA season was UNDEFEATED at 79 benefits and no failures!
I have produced 2 bets with regard to the NBA in addition to 17 bets and so far with typically the MLB season. Right here are my outcomes thus far:
OUR NBA RESULTS
3/26 Los Angeles La lakers vs. Detroit Appui
Even though I love the Pistons, I used to be advised to bet on the Lakers to win the game, and naturally these people did and We won the guess.
6/09 Los Angeles Lakers vs. Orlando Magic
It had been Game 3 regarding the NBA Ultimes and even even though the Magic shot over 62% for the game, and 74% in the very first half, they hardly squeaked by having a win 108-104. I truly thought Kobe would be his usual home and pull it with a succeed towards the end, but he missed some free of charge throws towards the end along with the Wonder went on to be able to win the online game, for his or her first earn from the series, because well as inside franchise history. Young man is i not glad that I’m using typically the Sports Betting Samsung champ c3300k! Another win for me personally.
MY MLB BENEFITS
5/1 Seattle Mariners vs. Oakland Athletics
I was told to bet about the Athletics within this game at +1. 5 and I’m glad I had because even nevertheless the A’s had been ahead most of the adventure, the Mariners emerged back at the end and received the game within the 9th inning simply by one run 8-7. I of study course, won this bet.
5/21 Texas Rangers or Detroit Tigers
The Rangers were the underdog with +1. 5 inside this game plus they ended upward losing by 1 run. The Rangers trailed the whole game just about, until the 8th inning when they tied up up at 3-3. ยูฟ่าเบท999 gone on to win in the 9th by way of a score regarding 4-3. I earned one more.
5/25 Fl Marlins vs. Phila. Phillies
I really thought the Phillies would win this particular game because they seem to be the better team, on the other hand I was recommended to bet for the Marlins +1. 5 and the Marlins won 5-3, even though Ryan Howard hit two homers. One more get for me.
5/25 St Louis Capital or Milwaukee Makers
This game was initially a pitchers cartouche between the Capital Chris Carpenter and the Brewers Yovani Apuesto. There was no score after nine innings, so that went into extras. In the 10th inning, an mistake by the Capital came back to be able to haunt them when the Brewers Expenses Hall drove throughout the winning operate, making the ultimate score 1-0. We were told to be able to bet on the Capital +1. 5, in addition to since they lost by 1 work, I still earned the bet.
5/29 Boston Red Sox vs. Toront Orange Jays
The Orange Jays pitcher Casey Janssen threw 8 good innings and the Blue Jays beat the Sox 6-3. The particular Blue Jays were underdogs at plus1. 5, so We won once again.
6/10 Ny Yankees vs. Boston Red Sox
The Reddish Sox stayed great against the Yankees this season, in addition to took over first location in the United states League East. That they edged out the Yankees with the 6-5 win. I actually picked the Yankees at +1. 5 and since the particular Yankees only missing by one operate, I won some sort of bet once again.
There is no reason women with wide feet cannot benefit from the same shoes as women who wear an average width shoe. If you have large feet and want to start wearing women’s wide sandals it is possible to. All you require is a amount of help to choose exactly the type of shoe that will fit your feet. With these helpful tips that you have learned, you are able to show your feet and get outside of your comfortable zone https://cartfolder.com/.
First, you need to let go of the notion that you don’t have a choice according to the past. Over the last five years, the choices for women’s wide sandal shoes have expanded so today, there is a wide selection of kind of style, color, and even wide shoes from any of the top designers. As they are made of top quality materials and are of good quality you can purchase footwear from a wide range of brands.
When you’re choosing women’s wide sandal shoes it is recommended to stay clear of styles that have ankle straps. While this type of shoe is great for most women, they may make women’s legs appear bulky and the feet appear wider. It is better to use a belt that runs around the back and one across the top is the best option, however even these should be narrow.
Material is another crucial selection factor when it comes to women’s wide sandals. The purchase of sandals made of heavy leather should be avoided. There are many options for leather but the sandals should be made with darker colored leather and in addition, the straps need to be thin. In order to make your feet appear thinner and smaller light colored straps and leather should always be avoided.
It is also essential to support. Sometimes, women feel a little unbalanced in normal sandals due in part to the footwear not designed specifically for wider feet. So, when searching for women’s wide sandals, the shoe needs to provide adequate support. Apart from making it easy to walk in sandals, it will also help with balance so your feet, as well as the hips and back don’t get stressed.
Wedge sandals are an ideal choice for women’s wide sandal shoes. This style has the stability required for an elongated foot, yet the design is elegant. The wedge is also available in a range of styles colours, styles, and accessories to allow you to pick what suits you best. Just remember when choosing shoes with embellishments for wider feet that the width is not too large. Otherwise, embellishments and accents that are too big will make the look of your foot larger.
Every woman of today has her own pair of sandals. Sandals are similar to an individual woman’s shoe. It is a distinctive accessory to give a picture of the woman’s style. Many women own at least two pairs of sandals. This is for their different clothes to wear because there are various kinds of sandals and for different occasions.
Nowadays, sandals aren’t just for women. They are now also for men. These sandals are perfect for a stroll at the sea or walking around the mall since they are comfortable to wear and are easy to remove also. Wearing it is better than wearing ordinary slippers since they are more elegant and trendy at the same while. Similar to slippers, they are extremely comfortable to wear, and cool while at the same time.
The sandals worn by women of today are an ideal alternative to heels and stilettos. They are now considered formal style of footwear, not to mention being generally considered casual clothing solely. Aside from being elegant and fashionable footwear there are also sandals intended for running, walking, or solely for trails. They are available in the moment and since they’re not the same as typical stilettos or shoes, they’re extremely comfortable to wear. Although there are sandals have the appearance of a typical stiletto, or shoe, that could cause abrasions, cuts or ingrown, there are also sandals that can give you the comfort that you’re looking for in a shoe. They are called women’s comfort sandals. This provides the most quality of comfort that footwear can offer. There are sandals with very small heels or sandals without heels in any way. These sandals are more comfortable than those that have high heels.
Men on the other hand tend to wear sandals with certain outfits. It is more formal looking to be a man with an elegant black shoe with his tie and suit. There are also sandals for men which are lovely to put on when in casual attire.
Sandals are used for a variety of reasons, it is not made exclusively for women, but can be worn by men as well and works well for them. Sandals are by far the perfect footwear for casual outfits.
Winter weather can greatly impact the structural integrity of your home, especially snow and ice. Roofing contractors in northern regions offer winter cleaning services to remove dangerous amounts of precipitation. To keep you and your family safe and to minimize the risk of permanent damage, you should be aware of potential hazards and know when it is time to call the professionals.
In 1975, stricter residential housing codes were enacted. Homes built before these regulations may not be strong enough to handle a particularly harsh winter without extra attention. If your roof was built after 1975 and is up to code, it should be able to withstand the heaviest average snow for your region cost of torch down roofing materials. Even newly constructed homes, however, have their limits. In general, removing snow that’s 18 inches or more is advised.
While the amount is important to note, the type should also be considered. New precipitation is the lightest, but it could melt and refreeze, creating additional weight. Thirty-eight inches of dry snow, also known as fresh snow, is equal to the weight of just six inches of wet snow. Ice is the heaviest and, therefore, poses the greatest risk. As a homeowner, you should determine the makeup of the precipitation and then look for signs of structural trouble.
There are certain indicators that point to permanent damage. Some signs of a stressed roof include sagging ceiling tiles, popping or creaking noises, cracked walls, or a leaking roof. Take note if interior doors are starting to stick. This could be a sign that the weight on the central structure is distorting the doorframe. Double check the drywall or plaster around the frame for visible cracks. If there is structural damage, a professional consultation will help you target the weak areas and find solutions.
Hiring a professional each season is far less expensive than paying for repairs or replacement caused by winter weather. Immediately after severe snowfalls, stress caused by the weight and pressure can cause structural damage. Removal crews have the special ladders, safety ropes, and tools that are needed to efficiently remove all snow and ice. They will analyze the pitch, shingles, and location to determine how much precipitation needs to be removed and the best possible removal plan.
Perekonomian dunia sedang tidak terlalu baik. Biaya hidup semakin tinggi setiap hari. Oleh karena itu terserah kepada setiap individu untuk menggunakan segala cara yang mungkin untuk mendapatkan tangan yang lebih baik di dunia saat ini BK8 link . Ada banyak pilihan yang bisa digunakan orang untuk membuat sumber penghasilan tambahan. Namun, penting untuk dipahami bahwa tidak ada opsi yang dipilih yang berfungsi lebih baik daripada bermain di kasino online. Ini adalah kemajuan baru dalam perjudian dan telah membawa sejumlah manfaat bagi dunia. Ada banyak alasan mengapa orang memilih kasino online daripada kasino berbasis darat.
Untuk memulainya, kasino online menawarkan rentang bonus yang lebih luas jika dibandingkan dengan rekan-rekan mereka yang berbasis darat. Ini adalah alasan utama mengapa kebanyakan orang beralih ke mereka. Karena kompetisi online yang tinggi, berbagai kasino online telah dipaksa untuk menggunakan segala cara yang mungkin untuk menarik sebanyak mungkin klien. Metode terbaik yang digunakan untuk mencapai tujuan ini telah ditemukan dalam pemberian bonus gratis. Ini bisa menjadi cara yang andal untuk menghasilkan lebih banyak uang dengan sedikit investasi.
Kenyamanan yang diciptakan oleh kasino online adalah alasan lain mengapa orang memilih perjudian online. Internet telah membawa sejumlah manfaat bagi dunia saat ini dalam hal kenyamanan. Tidak ada batasan waktu untuk bermain online. Semua yang diperlukan untuk berpartisipasi dengan andal di kasino online adalah mendapatkan komputer berkemampuan Internet dan akun dengan kasino yang andal. Tidak ada batasan waktu. Para pemain dapat memainkan permainan favorit mereka kapan saja sepanjang hari dari kenyamanan rumah mereka. Selain itu, selama seseorang memiliki perangkat berkemampuan Internet, dimungkinkan untuk berjudi dari bagian dunia mana pun.
Salah satu kerugian yang dibawa oleh permainan kasino adalah pemisahan anggota keluarga. Permainannya membuat ketagihan dan beberapa orang akhirnya menghabiskan berjam-jam di kasino darat. Selanjutnya, banyak keluarga yang berantakan. Ini tidak terjadi ketika datang ke kasino online. Para pemain diberi kesempatan untuk bertaruh dari kenyamanan rumah mereka sendiri. Akibatnya, anggota keluarga dapat menjadi dekat satu sama lain hampir sepanjang waktu.
Alasan utama mengapa game online lebih disukai daripada game berbasis darat adalah karena tidak ada penundaan. Di kasino darat, pemain menghabiskan banyak waktu menunggu meja kosong. Ini adalah aspek yang mengecilkan hati yang telah membuat kebanyakan orang kehilangan minat pada permainan. Namun, di kasino online, tabelnya digital; ini berarti mereka tidak dapat ditempati semua. Pemainnya juga banyak.
When it comes to choosing footwear for women who have large foot typically, they are faced with a limited or even no options. With internet access and the World Wide Web dominating every aspect of our lives, looking for the most sexy wide-width shoes is much easier than you could ever imagine https://bestpolos.com/how-to-stretch-sandals-for-wide-feet/.
You can choose from an incredible selection of sexy sneakers for all sizes and shapes. If your local mall isn’t satisfying you it’s time to take a look at the incredible selection of sexy wide width footwear here. There’s no need to squeeze your feet into a poorly fitted shoe and walk in discomfort. You’re now ready to find your sexy gait by wearing the most sexy wide width footwear
If you believe that wide-footed shoes are a embarrassing thing in the fashion world, you’ll be able to change your mind when you look at this selection. From high-heeled thigh boots up to Mary Jane shoes, you’ll find the most elegant wide width footwear on this page.
To experience the irresistible blend of style and comfort look into the Women’s 4 Inch Sexy Thigh-High Boot that comes with an ultra wide shaft as well as the 5 inch Super Wide Shaft High Heel Boot with side zips. The ultra-wide shafts give you the space you need for your feet to be comfortable, and the pointed heels are sexy and provide the sought-after style factor.
You can bring a man to his knees in a flash by wearing an enthralling dress and a sexy high-heeled shoes similar to the women’s wide Width 4-inch Sexy Red Patent Mary Jane Platform Shoe.
If you’d like to be able to effortlessly walk the streets in your style, then are in the right place!
In case you’ve got a feet that is wide in dimensions and the regular footwear is too tight and uncomfortable, then footwear for feet with wide widths are the right choice.
Shoes are essentially similar to other items of clothing. If they aren’t properly fitted they will not look great however, they could also make you uncomfortable. There’s no need for wearing shoes that do not fit well because there are many retailers that offer shoes that are suitable for people with wide feet. The first place I’d recommend you to start is via the Internet. You can get your shoes delivered right to your door. What’s more convenient?
A lot of the stores that sell sporting products are also excellent locations to go to. Contact the sales associate for help, and they’ll be happy to point you towards their range of footwear designed for those with a larger foot. On the boxes, there is the letter “W” or some other sign that the shoe was made for a wider foot. The shoes are typically clear so that you be aware of the type of shoe you’re buying.
Perhaps the best spot to purchase shoes in odd size is in big and tall stores. They specialize in sizes can be found in the racks, which means they are their bread-and-butter. If a tall and big shop has a section dedicated to shoes, as a lot do, then you’ll certainly be able to find an appropriate pair of shoes designed that are suitable for broad feet. They are perfect because they carry wide-footed shoes in a variety of styles such as casual, athletic formal, and casual.
As I mentioned earlier the largest shoe store is on the Internet. The Internet provides a variety of retailers that focus on selling footwear designed for big feet. There is one drawback: you aren’t able to try the shoes along with an forehand to determine whether they’re suitable. It’s really not an issue since I’m aware of several huge online shoe stores that provide free shipping even on returns. You really have nothing to lose.
Naturally, you’d like to stay clear of this, but there are some options to reduce the negative effects. First, ensure you’re wearing the correct size prior to buying shoes that are suitable for wide feet. Then, read carefully the return policy of their website. Certain online stores will allow returns provided that the shoes have not been used. The majority of the time, special footwear is more expensive, however it is possible to save when buying on Internet because there are many stores to choose from.
One of the best options in case you are unable to find shoes in other stores is to consult an orthopedic doctor. Orthopedic specialists are experts who can guide you in the right direction regarding where to purchase shoes that are suitable for wider feet and what kind of shoes would be the best fit for your needs.
I’m sure this is saying the obvious, but it’s vital to buy shoes that you are easy to put on. It’s possible to do some research and some work, but you’ll eventually discover shoes that fit as if you were wearing gloves. Shoes designed for wider feet are the extremely attractive and I’ll take a bite of your hat if someone could tell these from normal shoes.
Finding the ideal fitness shoes isn’t always as simple as it seems. A lot of people have major issues due to the size of their shoes. Some people have large feet or very small feet. Many people don’t even consider this issue because they wear shoes of average size and can locate their shoes at any shop that sells these types of footwear.
Being a man and have big feet can be a challenge to find this kind of footwear, however men typically just order them regardless of whether it cost more, and that’s the reason. They don’t seem to be experiencing any social discomfort due to having large feet.
But being a woman and having big feet seems to be more difficult than being a man who have large feet. Women are not as simple as investing a bit more money and a special order for shoes. Women are faced with an issue of social standing to the issue. Being a woman and have big feet could be embarrassing. On top of that , wearing gym shoes can only enhance the perception that your feet are large.
This is a major issue for women with large feet. However, I personally recommend that you purchase gym shoes in darker hues, as darker shades make your feet appear smaller. Additionally, if you have small feet, you should purchase shoes with lighter shades since these colors can make your feet appear larger.
Therefore, do not be hesitant or anxious when you are shopping for your gym sneakers anymore. Just buy them in the correct color and wear them with pride.
Athletic footwear is available in a variety of kinds and styles nowadays however, what is the most appropriate for the fitness center? I’d suggest the cross trainer as the best, or tennis shoes if you don’t have that cross-trainer. Running shoes are designed to move forward, but do not provide the stability required laterally for lifting weights heavy or for aerobics. Tennis shoes provide this lateral motion however, they may not have the cushioning forefoot that is present in cross-trainers.
Lifting weights demands a lot more stability in the lateral axis than one would think. Wearing the right quality shoes for men or shoes for women to perform such activities is crucial. The importance of footwear when it comes to training for weights should not be overlooked. Shoes that have an extremely low center of gravity but adequate cushioning is essential and a shoe that keeps the ankle in place and holds your feet in place where they are.
If aerobics or other exercises are being performed in the gym, it is important to ensure that the shoes you choose for your fitness center have a good amount of cushioning beneath the ball of your foot and also the heel, as a lot of aerobic exercise is performed while placing the weight on the front of your foot.
The process of fitting a shoe to the fitness center is the same as fitting any other type of shoe. Be sure that your feet are not sucked into the toe box, and your heel doesn’t slide when you tie the shoe to the top in the correct way. Be sure that the shoe fits comfortable from side to side, but doesn’t pinch or press on the sides of your toes. Make sure you test the shoes wearing the same socks of those you wear for a workout Always be sure to read the return policy of the retailer you are working with prior to making a purchase. This is particularly important when purchasing shoes online. It is essential to ensure that you’re working with a reliable company. If you do it right buying shoes online at a bargain online shoe store could be the most effective option.